In 2014, Anime Studio 10 contained upgraded features and new mechanics to its predecessor. In 2012, Smith Micro released Anime Studio 9, with new features including Smart Bones, Editable Motion Graphs, and Bézier handles, as well as enhancements to the timeline, key frames, and onionskins. Version 8.1 also supported the new Poser 9 SDK and integrated the Wacom multi-touch API, allowing it to work natively with Wacom's Bamboo and Intuos tablets. In 2011, Anime Studio 8 added features such as the Character Wizard, layered Photoshop import, and real-time media connection.

In 2010, Smith Micro released Anime Studio 7, which added features such as Physics, 3D creation and an improved interface. The software was distributed by E Frontier until 2007, when it was acquired by Smith Micro and renamed Anime Studio, as a marketing companion for the former Manga Studio. The software was originally developed under the name 'Moho' in 1999 by Mike Clifton at Lost Marble. It has two different packages: Moho Pro and Moho Debut, similar to the pro version but with features restricted. Moho (previously marketed as Anime Studio) is a proprietary vector-based 2D animation application distributed by Lost Marble LLC.

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